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KMID : 1007420110090030189
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Mood and Emotion
2011 Volume.9 No. 3 p.189 ~ p.193
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Interleukin-1β -511C/T Gene Polymorphism and Depression Related to Breast Cancer
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Kim Jae-Min
Kang Hee-Ju
Jang Ji-Eun
Kim Seon-Young
Kim Sung-Wan
Shin Il-Seon
Park Min-Ho
Yoon Jung-Han
Yoon Jin-Sang
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Abstract
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Objectives : Pro-inflammatory cytokines are related to the pathophysiology of both cancer and depression, and their secretion is controlled by the transcriptional activity of particular gene polymorphisms. This study aimed to investigate whether interleukin (IL)-1β -511C/T gene polymorphism is associated with depression following mastectomy for breast cancer.
Methods : A total of 309 patients with breast cancer were evaluated one week after mastectomy, and 244 (79%) were followed one year later. Depression (major+minor depressive disorders) was diagnosed according to DSM-IV criteria using the Mini International Neuropsychiatric Interview, and classified into prevalent, persistent, and incident depression. Associations of IL-1β -511C/T polymorphism with the three depressive status were estimated using logistic regression models.
Results : At baseline, 74 (24%) patients were classified with prevalent depression ; and at follow up, 19 (8%) and 25 (10%) patients were classified with persistent and incident depression, respectively. The IL-1β -511T/T genotype was independently associated with prevalent and persistent depression, but not with incident depression.
Conclusion : IL-1β -511T/T genotype may involve in the etiology of depression occurring in women with breast cancer who receive a mastectomy.
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KEYWORD
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Breast cancer, Depression, Genetic association study, Interleukin-1β -511C/T gene polymorphism, Cytokine
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